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The origins of ayahuasca are not clear to archaeologists. While there is evidence of similar psychoactive preparations to ayahuasca being used thousands of years ago, many indigenous cultures of the Amazon Rainforest appear to have adopted ayahuasca relatively recently.

Recent studies have illustrated fascinating insights about how ayahuasca effects the human brain. Different molecules in the brew interact with different parts of the brain to produce a complex therapeutic and spiritual experience.

The feeling of accessing a deeper reality that is essential or fundamental unites different ayahuasca traditions. But the spiritual experiences of ayahuasca may vary across individuals and cultures. Many things can influence an ayahuasca experience.